Folic acid protects and heals gastric mucosa: role of acid output, inflammatory cytokines, angiogenic and growth factors

Abstract Background Folic acid modulates gastrointestinal inflammatory disorders via a number of suggested gastroprotective mechanisms. Gastric acid, inflammation, cell proliferation and angiogenesis play significant role in gastroprotection restoration mucosal integrity following injury. This two-section-study assessed (1) output, parietal mass, neutrophil infiltration inflammation after 6 h pyloric ligation, (2) healing mucosa acetic induced gastric ulcer albino Wistar rats upon pre-treatment with (FA). Results significantly lessens the injury associated pylorus ligation dose-dependent manner. Acid mass reduced when compared control group. In group, FA equally severity ( p < 0.05). Moreover, EGFR Ki-67 were enhanced, while CD31 Factor VIII enhanced only on day 10. Also, EGF VEGF but TNF-α IL-1β suppressed favour IL-4 IL-10 dose-dependently both studies. Conclusion These results suggest that folic supplementation protects stomach also accelerates ulcers angiogenesis.